id	title	transfer_domain	bfi_score	feasibility_tier	particle_diameter_nm	zeta_potential_mv	endosomal_escape_score	macrophage_stealth_score	physical_barriers	mechanism	primary_doi
CDI-004	Airway Secretory-to-Basal Dedifferentiation via Transient Notch Reprogramming	epithelial_plasticity	0.9450	HIGH_FEASIBILITY	50.0	0.0	0.92	0.90	Basal niche inaccessibility; tight junction penetration requirement	Facultative lineage plasticity: committed luminal secretory cells (SCGB1A1+) dedifferentiate into multipotent basal stem cells (KRT5+/TP63+) upon transient Notch inhibition.	10.1038/nature12777
CDI-002	Low-Affinity Transferrin Receptor (TfR1) Monovalent Transcytosis	blood_brain_barrier	0.9125	HIGH_FEASIBILITY	55.0	-1.0	0.90	0.85	Epithelial tight junctions; endosomal/lysosomal degradation pathway	Tuning ligand binding affinity (Kd = 200-400 nM) avoids lysosomal sorting, redirecting internalized vesicles to Rab11a exocytosis pathways across tight junctions.	10.1126/scitranslmed.3002230
CDI-003	Polysarcosine (pSar) Biodegradable Stealth & Ester-Cleavable Ionizable Lipids	mucosal_immunology	0.9085	HIGH_FEASIBILITY	75.0	0.5	0.88	0.98	Polyanionic mucin adhesion; alveolar macrophage TLR7/8 activation and PEG clearance	Replaces immunogenic PEG conjugates with non-immunogenic polysarcosine (pSar); incorporates enzymatic ester cleavable aliphatic tails (macrophage t1/2 < 4h).	10.1039/c9bm01314d
CDI-001	CendR / NRP-1 Proteolytic Internalization & Mucinase Liquefaction	solid_tumor_desmoplasia	0.8600	HIGH_FEASIBILITY	65.0	-2.5	0.85	0.80	Sputum mucin meshwork steric entrapment; apical endocytic barrier	iRGD / C-end Rule peptide activation of Neuropilin-1 (NRP-1) macropinocytosis coupled with StcE mucin-cleaving protease (Malaker et al. PNAS 2019, DOI: 10.1073/pnas.1813020116).	10.1016/j.ccr.2009.11.002
CDI-005	Sendai Virus F/HN Pseudotyped Enveloped Delivery Vehicles (EDVs)	synthetic_virology	0.8353	MODERATE_FEASIBILITY	95.0	-4.0	0.99	0.82	Mucosal endosomal entrapment; lysosomal TLR pattern recognition	Hemagglutinin-neuraminidase (HN) binds apical sialic acid; fusion (F) protein mediates direct pH-independent membrane fusion at the apical plasma membrane.	10.1016/S2213-2600(15)00245-3