/* Interactive Prime Editing Feasibility Explorer Component (T-0209) */
.prime-sim-wrap {
  margin: 3.5rem auto;
  padding: 0;
  max-width: 100%;
}

.prime-sim-container {
  background: var(--bg-panel);
  border: 1px solid var(--border-glass);
  border-radius: var(--radius-md);
  padding: clamp(1rem, 3vw, 1.75rem);
  box-shadow: 0 4px 24px rgba(0, 0, 0, 0.4);
  max-width: 100%;
  overflow: hidden;
}

.prime-sim-header {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  flex-wrap: wrap;
  gap: 1rem;
  margin-bottom: 1.5rem;
  padding-bottom: 1.25rem;
  border-bottom: 1px solid var(--border-subtle);
}

.prime-sim-title-group {
  max-width: 52rem;
}

.prime-track-badge {
  display: inline-block;
  margin-bottom: 0.5rem;
  font-size: 0.75rem;
  font-family: var(--font-mono);
  color: var(--neon-cyan);
}

.prime-sim-title {
  font-family: var(--font-display);
  font-size: clamp(1.2rem, 3vw, 1.6rem);
  font-weight: 700;
  color: var(--ink-primary);
  margin: 0 0 0.5rem;
}

.prime-sim-sub {
  font-size: 0.95rem;
  color: var(--ink-secondary);
  line-height: 1.55;
  margin: 0;
}

.prime-variant-switch {
  display: flex;
  flex-wrap: wrap;
  gap: 0.5rem;
}

.prime-variant-btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 2.75rem;
  background: rgba(255, 255, 255, 0.06);
  border: 1px solid rgba(255, 255, 255, 0.15);
  color: var(--ink-secondary);
  padding: 0.45rem 1rem;
  border-radius: 999px;
  font-size: 0.85rem;
  font-family: var(--font-body);
  font-weight: 500;
  cursor: pointer;
  transition: all 0.15s ease;
}

.prime-variant-btn:hover {
  background: rgba(255, 255, 255, 0.12);
  color: var(--ink-primary);
}

.prime-variant-btn.active,
.prime-variant-btn[aria-pressed="true"] {
  background: var(--neon-cyan);
  border-color: var(--neon-cyan);
  color: #050505;
  font-weight: 600;
}

.prime-sim-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 1.5rem;
  margin-bottom: 1.5rem;
}

@media (min-width: 860px) {
  .prime-sim-grid {
    grid-template-columns: 1.15fr 0.85fr;
  }
}

.prime-controls-col {
  display: flex;
  flex-direction: column;
  gap: 1.25rem;
}

.prime-slider-control {
  background: rgba(255, 255, 255, 0.02);
  border: 1px solid var(--border-glass);
  border-radius: 6px;
  padding: 0.9rem 1rem;
}

.prime-slider-label-row {
  display: flex;
  justify-content: space-between;
  align-items: center;
  margin-bottom: 0.35rem;
  flex-wrap: wrap;
  gap: 0.5rem;
}

.prime-slider-title {
  font-family: var(--font-body);
  font-weight: 600;
  font-size: 0.9rem;
  color: var(--ink-primary);
}

.prime-slider-badge {
  font-family: var(--font-mono);
  font-size: 0.85rem;
  color: var(--neon-cyan);
  background: rgba(0, 212, 255, 0.1);
  padding: 0.15rem 0.5rem;
  border-radius: 4px;
}

.prime-slider-desc {
  font-size: 0.825rem;
  color: var(--ink-secondary);
  line-height: 1.45;
  margin: 0 0 0.65rem;
}

.prime-range-input {
  width: 100%;
  accent-color: var(--neon-cyan);
  cursor: pointer;
}

.prime-select-row {
  display: flex;
  gap: 0.5rem;
  margin-top: 0.5rem;
  flex-wrap: wrap;
}

.prime-select-btn {
  background: rgba(255, 255, 255, 0.05);
  border: 1px solid rgba(255, 255, 255, 0.12);
  color: var(--ink-secondary);
  padding: 0.35rem 0.75rem;
  border-radius: 4px;
  font-size: 0.8rem;
  font-family: var(--font-mono);
  cursor: pointer;
  transition: all 0.15s ease;
}

.prime-select-btn:hover {
  background: rgba(255, 255, 255, 0.1);
  color: var(--ink-primary);
}

.prime-select-btn.active,
.prime-select-btn[aria-pressed="true"] {
  background: rgba(0, 212, 255, 0.18);
  border-color: var(--neon-cyan);
  color: var(--neon-cyan);
  font-weight: 600;
}

.prime-gauge-col {
  display: flex;
  flex-direction: column;
  gap: 1.25rem;
}

.prime-gauge-card {
  background: rgba(10, 10, 15, 0.7);
  border: 1px solid var(--border-glass);
  border-radius: 6px;
  padding: 1.25rem;
  text-align: center;
}

.prime-gauge-title {
  font-size: 0.8rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  font-family: var(--font-mono);
  color: var(--ink-secondary);
  margin-bottom: 0.5rem;
}

.prime-gauge-value {
  font-family: var(--font-mono);
  font-size: clamp(2rem, 5vw, 2.75rem);
  font-weight: 700;
  color: var(--neon-cyan);
  margin-bottom: 0.35rem;
}

.prime-gauge-value.optimal {
  color: #10b981;
}

.prime-gauge-value.suboptimal {
  color: #f59e0b;
}

.prime-gauge-value.hazard {
  color: #ef4444;
}

.prime-gauge-status {
  font-size: 0.85rem;
  font-weight: 600;
  color: #10b981;
  margin-bottom: 1rem;
}

.prime-gauge-status.status-suboptimal {
  color: #f59e0b;
}

.prime-metrics-row {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 0.75rem;
  margin-bottom: 1rem;
  text-align: left;
}

.prime-submetric {
  background: rgba(255, 255, 255, 0.03);
  padding: 0.5rem 0.65rem;
  border-radius: 4px;
}

.prime-submetric-label {
  display: block;
  font-size: 0.75rem;
  color: var(--ink-secondary);
  margin-bottom: 0.2rem;
}

.prime-submetric-val {
  font-family: var(--font-mono);
  font-size: 0.95rem;
  font-weight: 600;
  color: var(--ink-primary);
}

.prime-delivery-card {
  background: rgba(255, 255, 255, 0.02);
  border: 1px solid var(--border-glass);
  border-radius: 6px;
  padding: 1rem;
}

.prime-delivery-title {
  font-family: var(--font-mono);
  font-size: 0.8rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--neon-cyan);
  margin-bottom: 0.75rem;
  display: flex;
  align-items: center;
  gap: 0.4rem;
}

.prime-vector-list {
  display: flex;
  flex-direction: column;
  gap: 0.5rem;
}

.prime-vector-item {
  display: flex;
  justify-content: space-between;
  align-items: center;
  font-size: 0.825rem;
  padding: 0.4rem 0.6rem;
  background: rgba(0, 0, 0, 0.2);
  border-radius: 4px;
}

.prime-vector-name {
  color: var(--ink-primary);
}

.prime-vector-badge {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  padding: 0.15rem 0.45rem;
  border-radius: 3px;
}

.prime-vector-badge.feasible {
  background: rgba(16, 185, 129, 0.15);
  color: #10b981;
}

.prime-vector-badge.infeasible {
  background: rgba(239, 68, 68, 0.15);
  color: #ef4444;
}

.prime-schematic-wrap {
  position: relative;
  width: 100%;
  border-radius: 6px;
  overflow: hidden;
  border: 1px solid var(--border-glass);
  background: #08080c;
  margin-bottom: 0.75rem;
}

.prime-canvas-controls {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 0.5rem 0.75rem;
  background: rgba(0, 0, 0, 0.35);
  border-bottom: 1px solid var(--border-glass);
}

.prime-canvas-title {
  font-family: var(--font-mono);
  font-size: 0.8rem;
  color: var(--ink-secondary);
}

.prime-canvas-pause-btn {
  background: rgba(255, 255, 255, 0.06);
  border: 1px solid rgba(255, 255, 255, 0.15);
  color: var(--ink-secondary);
  padding: 0.25rem 0.65rem;
  border-radius: 4px;
  font-size: 0.75rem;
  font-family: var(--font-mono);
  cursor: pointer;
}

.prime-canvas-pause-btn:hover {
  background: rgba(255, 255, 255, 0.12);
  color: var(--ink-primary);
}

.prime-canvas {
  display: block;
  width: 100%;
  aspect-ratio: 21 / 9;
  height: auto;
  min-height: 190px;
}

@media (max-width: 1024px) {
  .prime-canvas {
    aspect-ratio: 16 / 9;
  }
}

@media (max-width: 640px) {
  .prime-canvas {
    aspect-ratio: 16 / 10;
    min-height: 175px;
  }
}

.prime-caption {
  font-size: 0.85rem;
  font-style: italic;
  color: var(--ink-secondary);
  margin: 0.5rem 0 1.25rem;
  line-height: 1.45;
}

.prime-presets-bar {
  display: flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 0.5rem;
  margin-bottom: 1rem;
  padding-top: 1rem;
  border-top: 1px solid var(--border-subtle);
}

.prime-presets-label {
  font-size: 0.85rem;
  font-weight: 600;
  color: var(--ink-primary);
  margin-right: 0.25rem;
}

.prime-preset-btn {
  background: rgba(255, 255, 255, 0.05);
  border: 1px solid rgba(255, 255, 255, 0.12);
  color: var(--ink-secondary);
  padding: 0.4rem 0.8rem;
  border-radius: 999px;
  font-size: 0.8rem;
  font-family: var(--font-body);
  cursor: pointer;
  transition: all 0.15s ease;
}

.prime-preset-btn:hover {
  background: rgba(255, 255, 255, 0.1);
  color: var(--ink-primary);
}

.prime-preset-btn.highlight-curative {
  border-color: rgba(0, 212, 255, 0.4);
  color: var(--neon-cyan);
}

.prime-preset-btn.highlight-curative:hover {
  background: rgba(0, 212, 255, 0.12);
}

.prime-claims-card {
  background: rgba(255, 255, 255, 0.02);
  border: 1px solid var(--border-glass);
  border-radius: 6px;
  padding: 1rem;
  margin-top: 1rem;
}

.prime-claims-title {
  font-family: var(--font-mono);
  font-size: 0.85rem;
  color: var(--neon-cyan);
  margin: 0 0 0.5rem;
}

.prime-claims-list {
  display: flex;
  flex-direction: column;
  gap: 0.5rem;
  font-size: 0.8rem;
  color: var(--ink-secondary);
  line-height: 1.45;
}

.prime-claim-item strong {
  color: var(--ink-primary);
}

.prime-claim-item a {
  color: var(--neon-cyan);
  text-decoration: underline;
}

.prime-disclaimer-note {
  font-size: 0.825rem;
  color: var(--ink-secondary);
  margin-top: 0.75rem;
  line-height: 1.5;
  border-left: 2px solid var(--neon-cyan);
  padding-left: 0.75rem;
}

/* ==========================================================================
   NBD1 Thermal Unfolding (ΔTm) & Domain-Interface (ΔΔG) Explorer (T-0209 & Wave 7)
   ========================================================================== */
.pe-explorer-section {
  margin: 3.5rem auto;
}

.nbd1-container {
  background: var(--surface-1, #0c1017);
  border: 1px solid rgba(255, 255, 255, 0.08);
  border-radius: 12px;
  padding: 2rem;
  box-shadow: 0 12px 36px rgba(0, 0, 0, 0.45);
}

.nbd1-header {
  margin-bottom: 1.75rem;
}

.nbd1-title-group {
  margin-bottom: 1.5rem;
}

.nbd1-title {
  font-family: var(--font-display, "Space Grotesk", sans-serif);
  font-size: 1.6rem;
  font-weight: 700;
  color: var(--ink-primary, #f0f4f8);
  margin: 0.5rem 0;
  line-height: 1.25;
}

.nbd1-sub {
  font-family: var(--font-body, system-ui, sans-serif);
  font-size: 0.95rem;
  color: var(--ink-secondary, #94a3b8);
  line-height: 1.5;
  margin: 0;
  max-width: 65ch;
}

.nbd1-controls-row {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
  gap: 1.5rem;
  margin-top: 1.25rem;
  padding-top: 1.25rem;
  border-top: 1px solid rgba(255, 255, 255, 0.06);
}

.nbd1-control-block {
  display: flex;
  flex-direction: column;
  gap: 0.5rem;
}

.nbd1-control-label {
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 0.72rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--muted, #64748b);
}

.nbd1-btn-group {
  display: flex;
  flex-wrap: wrap;
  gap: 0.5rem;
}

.nbd1-select-btn {
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 0.78rem;
  font-weight: 500;
  padding: 0.5rem 0.85rem;
  min-height: 44px;
  border-radius: 6px;
  background: rgba(255, 255, 255, 0.03);
  color: var(--ink-secondary, #94a3b8);
  border: 1px solid rgba(255, 255, 255, 0.1);
  cursor: pointer;
  transition: all 0.15s ease-in-out;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  text-align: center;
}

.nbd1-select-btn:hover {
  background: rgba(255, 255, 255, 0.07);
  color: var(--ink-primary, #f0f4f8);
  border-color: rgba(255, 255, 255, 0.25);
}

.nbd1-select-btn:focus-visible {
  outline: 2px solid var(--neon-cyan, #00f3ff);
  outline-offset: 2px;
}

.nbd1-select-btn.active {
  background: rgba(0, 243, 255, 0.12);
  color: var(--neon-cyan, #00f3ff);
  border-color: rgba(0, 243, 255, 0.6);
  font-weight: 600;
  box-shadow: 0 0 12px rgba(0, 243, 255, 0.15);
}

.nbd1-viz-wrap {
  background: rgba(5, 8, 15, 0.85);
  border: 1px solid rgba(255, 255, 255, 0.08);
  border-radius: 8px;
  padding: 1rem 1rem 1.25rem 1rem;
  margin-top: 1.5rem;
}

.nbd1-viz-toolbar {
  display: flex;
  justify-content: space-between;
  align-items: center;
  margin-bottom: 0.75rem;
  padding: 0 0.25rem;
}

.nbd1-viz-status {
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 0.76rem;
  color: var(--muted, #64748b);
}

.nbd1-anim-btn {
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 0.72rem;
  font-weight: 600;
  padding: 0.35rem 0.75rem;
  min-height: 36px;
  border-radius: 4px;
  background: rgba(255, 255, 255, 0.04);
  color: var(--ink-secondary, #94a3b8);
  border: 1px solid rgba(255, 255, 255, 0.12);
  cursor: pointer;
  transition: all 0.15s ease-in-out;
}

.nbd1-anim-btn:hover {
  background: rgba(255, 255, 255, 0.08);
  color: var(--ink-primary, #f0f4f8);
  border-color: rgba(255, 255, 255, 0.25);
}

.nbd1-anim-btn:focus-visible {
  outline: 2px solid var(--neon-cyan, #00f3ff);
  outline-offset: 2px;
}

.nbd1-thermodynamics-svg {
  width: 100%;
  height: auto;
  display: block;
  overflow: visible;
}

/* SVG Interior Elements */
.nbd1-panel-rect {
  fill: rgba(14, 20, 32, 0.75);
  stroke: rgba(255, 255, 255, 0.08);
  stroke-width: 1;
}

.nbd1-panel-title {
  fill: var(--ink-primary, #f0f4f8);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 11px;
  font-weight: 600;
}

.nbd1-axis-line {
  stroke: rgba(255, 255, 255, 0.25);
  stroke-width: 1;
}

.nbd1-grid-dash {
  stroke: rgba(255, 255, 255, 0.06);
  stroke-dasharray: 2 4;
  stroke-width: 1;
}

.nbd1-axis-label {
  fill: var(--muted, #64748b);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 9px;
}

.nbd1-37-ref-line {
  stroke: #ff6b8b;
  stroke-width: 1.5;
  stroke-dasharray: 3 3;
}

.nbd1-ref-label {
  fill: #ff6b8b;
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 10px;
  font-weight: 600;
}

.nbd1-curve-path {
  fill: none;
  stroke: var(--neon-cyan, #00f3ff);
  stroke-width: 2.5;
  stroke-linecap: round;
}

.nbd1-tm-drop-line {
  stroke: var(--lime, #4ade80);
  stroke-width: 1.5;
  stroke-dasharray: 2 2;
}

.nbd1-tm-marker-circle {
  fill: var(--lime, #4ade80);
  stroke: #05080f;
  stroke-width: 2;
}

.nbd1-tm-marker-text {
  fill: var(--lime, #4ade80);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 10px;
  font-weight: 700;
}

.nbd1-bar-label {
  fill: var(--ink-secondary, #94a3b8);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 10px;
}

.nbd1-bar-track {
  fill: rgba(255, 255, 255, 0.05);
  stroke: rgba(255, 255, 255, 0.08);
}

.nbd1-bar-fill {
  transition: width 0.35s ease;
}

.nbd1-bar-fill.bar-stable,
.nbd1-bar-fill.bar-curative {
  fill: var(--lime, #4ade80);
}

.nbd1-bar-fill.bar-moderate {
  fill: var(--gold, #edbd45);
}

.nbd1-bar-fill.bar-unstable {
  fill: #ff6b8b;
}

.nbd1-bar-val-text {
  fill: var(--ink-primary, #f0f4f8);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 10px;
  font-weight: 600;
}

.nbd1-allosteric-bridge {
  stroke: rgba(0, 243, 255, 0.45);
  stroke-dasharray: 3 3;
  stroke-width: 1.5;
  fill: none;
}

/* Readout Grid */
.nbd1-readout-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(180px, 1fr));
  gap: 1rem;
  margin-top: 1.5rem;
}

.nbd1-readout-card {
  background: rgba(255, 255, 255, 0.025);
  border: 1px solid rgba(255, 255, 255, 0.08);
  border-radius: 8px;
  padding: 1rem;
  display: flex;
  flex-direction: column;
  gap: 0.35rem;
}

.nbd1-fis-card {
  grid-column: 1 / -1;
  border-left: 3px solid var(--neon-cyan, #00f3ff);
}

.nbd1-fis-val {
  font-size: 0.92rem;
  line-height: 1.45;
  color: var(--neon-cyan, #00f3ff);
}

.nbd1-card-lbl {
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 0.7rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--muted, #64748b);
}

.nbd1-card-val {
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 1.15rem;
  font-weight: 700;
  color: var(--neon-cyan, #00f3ff);
}

.nbd1-card-sub {
  font-family: var(--font-body, system-ui, sans-serif);
  font-size: 0.78rem;
  color: var(--ink-secondary, #94a3b8);
  line-height: 1.35;
}

.nbd1-disclaimer {
  font-family: var(--font-body, system-ui, sans-serif);
  font-size: 0.78rem;
  color: var(--muted, #64748b);
  margin-top: 1.25rem;
  padding-top: 1rem;
  border-top: 1px solid rgba(255, 255, 255, 0.06);
  font-style: italic;
  line-height: 1.45;
}

/* Reduced Motion & Pause */
.nbd1-thermodynamics-svg.is-anim-paused .svg-draw-line {
  animation-play-state: paused !important;
}

@media (prefers-reduced-motion: reduce) {
  .nbd1-thermodynamics-svg .svg-draw-line {
    animation: none !important;
    transition: none !important;
  }
}



/* Gating Potentiator Explorer SVG Styles (T-0280) */
.nbd1-curve-wt {
  fill: none;
  stroke: var(--neon-cyan, #00f3ff);
  stroke-width: 2.5;
  stroke-linecap: round;
}

.nbd1-curve-mut {
  fill: none;
  stroke: var(--gold, #f59e0b);
  stroke-width: 2.5;
  stroke-dasharray: 4 3;
  stroke-linecap: round;
}

.nbd1-grid-line {
  stroke: rgba(255, 255, 255, 0.08);
  stroke-width: 1;
}

.nbd1-ref-dashed {
  stroke: #ff6b8b;
  stroke-width: 1.5;
  stroke-dasharray: 3 3;
}

.nbd1-axis-label-right {
  fill: var(--muted, #64748b);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 9px;
  text-anchor: end;
}

.nbd1-state-box {
  fill: rgba(30, 41, 59, 0.85);
  stroke: rgba(0, 243, 255, 0.35);
  stroke-width: 1;
}

.nbd1-state-text {
  fill: var(--ink-primary, #f0f4f8);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 11px;
  font-weight: 600;
}

.nbd1-cycle-arrow {
  stroke: var(--muted, #94a3b8);
  stroke-width: 1.5;
}

.nbd1-badge-energy {
  fill: var(--lime, #4ade80);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 12px;
  font-weight: 700;
}

.nbd1-badge-coop {
  fill: var(--cyan, #00f3ff);
  font-family: var(--font-mono, "IBM Plex Mono", monospace);
  font-size: 10px;
  font-weight: 600;
}