/* Styles for In Silico Delivery Hypothesis Explorer (/cf/delivery/)
   Adheres to modern-web-standards (container queries, CSS nesting, semantic variables)
   and WCAG AA accessibility budgets. Strict CSP (style-src-attr 'none'). */

.delivery-main {
  width: 100%;
  max-width: var(--wide);
  margin: 0 auto;
  padding: 1.5rem 1rem 4rem;
}

.delivery-hero {
  margin-bottom: 2rem;
}

.delivery-title {
  font: 600 clamp(2rem, 5vw, 3.25rem) var(--font-display);
  line-height: 1.1;
  color: var(--ink-primary);
  margin: 0.5rem 0 0.75rem;
  letter-spacing: -1px;
}

.delivery-subtitle {
  font: 400 1.05rem var(--font-body);
  color: var(--ink-secondary);
  max-width: 52rem;
  line-height: 1.55;
  margin: 0 0 1.25rem;
}

/* Dignity Boundary Card (Permanent, Non-Dismissible) */
.dignity-boundary-card {
  background: rgba(237, 189, 69, 0.06);
  border: 1px solid rgba(237, 189, 69, 0.4);
  border-left: 4px solid var(--lime);
  border-radius: 8px;
  padding: 1rem 1.25rem;
  margin-bottom: 2rem;
  display: flex;
  flex-direction: column;
  gap: 0.5rem;
  backdrop-filter: blur(8px);
  -webkit-backdrop-filter: blur(8px);
}

.dignity-card-header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: 0.75rem;
}

.dignity-badge-wrap {
  display: flex;
  align-items: center;
  gap: 0.5rem;
}

.dignity-tag {
  font: 600 0.75rem var(--font-mono);
  text-transform: uppercase;
  letter-spacing: 0.05em;
  padding: 0.2rem 0.5rem;
  border-radius: 4px;
  background: rgba(237, 189, 69, 0.2);
  color: var(--lime);
}

.t2-cert-badge {
  font: 600 0.75rem var(--font-mono);
  letter-spacing: 0.03em;
  padding: 0.2rem 0.6rem;
  border-radius: 4px;
  background: rgba(0, 243, 255, 0.15);
  color: var(--neon-cyan);
  border: 1px solid rgba(0, 243, 255, 0.4);
}

.dignity-statement {
  font: 500 0.92rem var(--font-body);
  color: var(--ink-primary);
  line-height: 1.5;
  margin: 0;
}

/* Container Queries Wrapper */
.delivery-container {
  container-type: inline-size;
  container-name: delivery-explorer;
  display: flex;
  flex-direction: column;
  gap: 2rem;
}

/* Controls Panel */
.delivery-controls-panel {
  background: var(--bg-panel);
  border: 1px solid var(--border-glass);
  border-radius: 12px;
  padding: 1.25rem 1.5rem;
  display: flex;
  flex-direction: column;
  gap: 1.25rem;
}

.controls-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 1.5rem;
}

@container delivery-explorer (max-width: 720px) {
  .controls-grid {
    grid-template-columns: 1fr;
    gap: 1.25rem;
  }
}

.control-group {
  display: flex;
  flex-direction: column;
  gap: 0.5rem;
}

.control-label {
  font: 600 0.82rem var(--font-mono);
  color: var(--ink-secondary);
  text-transform: uppercase;
  letter-spacing: 0.05em;
  display: flex;
  justify-content: space-between;
  align-items: center;
}

.control-value {
  font: 600 0.9rem var(--font-mono);
  color: var(--neon-cyan);
}

/* Segmented Buttons for Airway Toggle */
.segmented-switch {
  display: flex;
  background: rgba(255, 255, 255, 0.04);
  border: 1px solid var(--border-glass);
  border-radius: 8px;
  padding: 3px;
  gap: 4px;
}

.switch-btn {
  flex: 1;
  background: transparent;
  border: none;
  border-radius: 6px;
  padding: 0.55rem 0.75rem;
  color: var(--ink-secondary);
  font: 500 0.85rem var(--font-body);
  cursor: pointer;
  transition: all 0.2s ease;
  min-height: 44px;
}

.switch-btn:hover {
  color: var(--ink-primary);
  background: rgba(255, 255, 255, 0.05);
}

.switch-btn.is-active,
.switch-btn[aria-pressed="true"] {
  background: rgba(0, 243, 255, 0.15);
  color: var(--neon-cyan);
  font-weight: 600;
  border: 1px solid rgba(0, 243, 255, 0.35);
}

/* Range Slider */
.range-slider-wrap {
  display: flex;
  flex-direction: column;
  gap: 0.35rem;
}

.delivery-slider {
  -webkit-appearance: none;
  appearance: none;
  width: 100%;
  height: 2.75rem;
  padding-block: 1.125rem;
  background-clip: content-box;
  border-radius: 4px;
  background-color: rgba(255, 255, 255, 0.14);
  outline: none;
  margin: 0;
  cursor: pointer;
}

.delivery-slider::-webkit-slider-thumb {
  -webkit-appearance: none;
  appearance: none;
  width: 24px;
  height: 24px;
  border-radius: 50%;
  background: var(--neon-cyan);
  cursor: pointer;
  box-shadow: 0 0 10px rgba(0, 243, 255, 0.5);
  border: 2px solid #ffffff;
}

.delivery-slider::-moz-range-thumb {
  width: 24px;
  height: 24px;
  border-radius: 50%;
  background: var(--neon-cyan);
  cursor: pointer;
  box-shadow: 0 0 10px rgba(0, 243, 255, 0.5);
  border: 2px solid #ffffff;
}

.slider-marks {
  display: flex;
  justify-content: space-between;
  font: 400 0.72rem var(--font-mono);
  color: var(--muted);
}

/* Warning Cards */
.warning-container {
  display: flex;
  flex-direction: column;
  gap: 0.85rem;
}

.warning-card {
  border-radius: 8px;
  padding: 0.85rem 1.1rem;
  display: flex;
  flex-direction: column;
  gap: 0.35rem;
  font: 400 0.88rem var(--font-body);
  line-height: 1.5;
  transition: all 0.3s ease;
}

.warning-card[hidden] {
  display: none;
}

.warning-card-amber {
  background: rgba(240, 120, 67, 0.12);
  border: 1px solid rgba(240, 120, 67, 0.5);
  border-left: 4px solid var(--coral);
  color: #ffc4a8;
}

.warning-card-red {
  background: rgba(255, 60, 60, 0.15);
  border: 1px solid rgba(255, 60, 60, 0.6);
  border-left: 4px solid #ff3c3c;
  color: #ffd0d0;
}

.warning-card-blue {
  background: rgba(0, 243, 255, 0.07);
  border: 1px solid rgba(0, 243, 255, 0.35);
  border-left: 4px solid var(--neon-cyan);
  color: #d0f7ff;
}

.warning-title {
  font: 700 0.82rem var(--font-mono);
  text-transform: uppercase;
  letter-spacing: 0.04em;
  display: flex;
  align-items: center;
  gap: 0.4rem;
}

/* Visualizer Cards & Layout */
.visualizer-section {
  display: flex;
  flex-direction: column;
  gap: 2rem;
}

.viz-card {
  background: var(--bg-panel);
  border: 1px solid var(--border-glass);
  border-radius: 12px;
  padding: 1.5rem;
  display: flex;
  flex-direction: column;
  gap: 1.25rem;
}

.viz-card-header {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  flex-wrap: wrap;
  gap: 0.75rem;
}

.viz-heading {
  font: 600 1.25rem var(--font-display);
  color: var(--ink-primary);
  margin: 0;
}

.viz-desc {
  font: 400 0.88rem var(--font-body);
  color: var(--ink-secondary);
  margin: 0.25rem 0 0;
  max-width: 48rem;
  line-height: 1.45;
}

/* Candidate Selector Chips */
.candidate-chips-wrap {
  display: flex;
  flex-wrap: wrap;
  gap: 0.5rem;
}

.candidate-chip {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  background: rgba(255, 255, 255, 0.04);
  border: 1px solid var(--border-glass);
  border-radius: 20px;
  padding: 0.45rem 0.9rem;
  font: 500 0.8rem var(--font-mono);
  color: var(--ink-secondary);
  cursor: pointer;
  transition: all 0.2s ease;
  min-height: 44px;
}

.candidate-chip:hover {
  color: var(--ink-primary);
  border-color: rgba(0, 243, 255, 0.4);
}

.candidate-chip.is-active,
.candidate-chip[aria-pressed="true"] {
  background: rgba(0, 243, 255, 0.15);
  border-color: var(--neon-cyan);
  color: var(--neon-cyan);
  font-weight: 600;
}

/* Radar & Trajectory SVG Wrappers */
.svg-chart-wrap {
  width: 100%;
  max-width: 100%;
  overflow: hidden;
  display: flex;
  justify-content: center;
  align-items: center;
  background: rgba(0, 0, 0, 0.3);
  border: 1px solid rgba(255, 255, 255, 0.04);
  border-radius: 8px;
  padding: 1rem;
}

.svg-chart {
  width: 100%;
  height: auto;
  max-height: 480px;
  display: block;
}

/* Detail Spec Box */
.detail-spec-box {
  background: rgba(255, 255, 255, 0.02);
  border: 1px solid var(--border-glass);
  border-radius: 8px;
  padding: 1rem;
  display: grid;
  grid-template-columns: 2fr 1fr;
  gap: 1rem;
}

@container delivery-explorer (max-width: 640px) {
  .detail-spec-box {
    grid-template-columns: 1fr;
  }
}

.spec-prop {
  font: 400 0.84rem var(--font-body);
  color: var(--ink-secondary);
  line-height: 1.5;
}

.spec-prop strong {
  color: var(--ink-primary);
  font-family: var(--font-mono);
  font-size: 0.8rem;
}

.spec-title {
  margin: 0 0 0.4rem;
  color: var(--ink-primary);
  font-family: var(--font-display);
  font-size: 1.1rem;
}

.spec-meta {
  margin: 0 0 0.5rem;
  font-size: 0.82rem;
  font-family: var(--font-mono);
  color: var(--neon-cyan);
}

.spec-para {
  margin: 0 0 0.5rem;
}

.spec-citation {
  margin: 0;
  font-size: 0.78rem;
  color: var(--muted);
  font-family: var(--font-mono);
}

.spec-tier {
  font-size: 0.72rem;
  color: #0aff0a;
  font-family: var(--font-mono);
  margin-top: 0.25rem;
}

.spec-prop-center {
  text-align: center;
}

.spec-bfi-badge {
  display: flex;
  flex-direction: column;
  justify-content: center;
  align-items: center;
  background: rgba(0, 243, 255, 0.05);
  border: 1px solid rgba(0, 243, 255, 0.2);
  border-radius: 6px;
  padding: 0.75rem;
}

.bfi-score-num {
  font: 700 1.8rem var(--font-mono);
  color: var(--neon-cyan);
}

.bfi-score-label {
  font: 600 0.72rem var(--font-mono);
  color: var(--muted);
  text-transform: uppercase;
}

.trajectory-badge-group {
  display: flex;
  gap: 0.75rem;
}

.trajectory-badge {
  padding: 0.4rem 0.8rem;
}

.cftr-badge-val {
  color: #0aff0a;
}

/* Chart Legends */
.chart-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 1rem;
  justify-content: center;
  padding: 0.5rem;
}

.legend-item {
  display: flex;
  align-items: center;
  gap: 0.4rem;
  font: 500 0.8rem var(--font-mono);
  color: var(--ink-secondary);
}

.legend-color-dot {
  width: 10px;
  height: 10px;
  border-radius: 50%;
  display: inline-block;
}

.legend-dot-secretory { background: #f07843; }
.legend-dot-intermediate { background: #edbd45; }
.legend-dot-basal { background: #00f3ff; }
.legend-dot-ciliated { background: #bc13fe; }
.legend-dot-threshold { background: #0aff0a; }

.legend-dot-apical { background: #9a9a9a; }
.legend-dot-surface { background: #edbd45; }
.legend-dot-internalized { background: #bc13fe; }
.legend-dot-lysosomal { background: #ff3c3c; }
.legend-dot-delivered { background: #00f3ff; }

/* Download Drawer & Cards */
.download-section {
  display: flex;
  flex-direction: column;
  gap: 1.25rem;
}

.download-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
  gap: 1rem;
}

.download-card {
  background: var(--bg-panel);
  border: 1px solid var(--border-glass);
  border-radius: 8px;
  padding: 1rem 1.15rem;
  display: flex;
  flex-direction: column;
  gap: 0.75rem;
  justify-content: space-between;
}

.download-card-title {
  font: 600 0.88rem var(--font-mono);
  color: var(--neon-cyan);
  word-break: break-all;
}

.download-card-meta {
  font: 400 0.78rem var(--font-body);
  color: var(--ink-secondary);
  line-height: 1.45;
}

.download-hash-row {
  display: flex;
  flex-direction: column;
  gap: 0.3rem;
  background: rgba(0, 0, 0, 0.4);
  padding: 0.5rem;
  border-radius: 4px;
  border: 1px solid rgba(255, 255, 255, 0.05);
}

.download-hash-label {
  font: 600 0.68rem var(--font-mono);
  color: var(--muted);
  text-transform: uppercase;
}

.download-hash-val {
  font: 400 0.72rem var(--font-mono);
  color: var(--ink-primary);
  word-break: break-all;
  user-select: all;
}

.download-actions {
  display: flex;
  flex-wrap: wrap;
  gap: 0.5rem;
  align-items: center;
}

.download-btn {
  display: inline-flex;
  align-items: center;
  gap: 0.4rem;
  background: rgba(0, 243, 255, 0.12);
  border: 1px solid rgba(0, 243, 255, 0.4);
  border-radius: 6px;
  color: var(--neon-cyan);
  padding: 0.45rem 0.85rem;
  font: 600 0.8rem var(--font-mono);
  text-decoration: none;
  cursor: pointer;
  transition: all 0.2s ease;
  min-height: 40px;
}

.download-btn:hover,
.download-btn:focus-visible {
  background: rgba(0, 243, 255, 0.25);
  color: #ffffff;
}

.copy-btn {
  background: rgba(255, 255, 255, 0.05);
  border: 1px solid var(--border-glass);
  border-radius: 6px;
  color: var(--ink-secondary);
  padding: 0.45rem 0.65rem;
  font: 500 0.75rem var(--font-mono);
  cursor: pointer;
  transition: all 0.2s ease;
  min-height: 40px;
}

.copy-btn:hover,
.copy-btn:focus-visible {
  color: var(--ink-primary);
  background: rgba(255, 255, 255, 0.1);
}

/* Dual-AAV Split-Intein & Delta-R Minigene Packaging Explorer (T-0210) */
#aav-packaging-explorer {
  scroll-margin-top: 4.8rem;
}

.aav-gauge-stage {
  background: rgba(10, 10, 14, 0.7);
  border: 1px solid rgba(255, 255, 255, 0.1);
  border-radius: 10px;
  padding: 1.25rem 1.5rem;
  margin: 1.5rem auto;
  display: flex;
  flex-direction: column;
  gap: 1rem;
}

.aav-gauge-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  flex-wrap: wrap;
  gap: 0.5rem;
}

.aav-gauge-title {
  font-family: var(--font-mono);
  font-size: 0.88rem;
  font-weight: 600;
  color: var(--ink-primary);
  text-transform: uppercase;
  letter-spacing: 0.04em;
}

.aav-gauge-svg {
  width: 100%;
  height: auto;
  display: block;
}

.aav-bar-bg {
  fill: rgba(255, 255, 255, 0.06);
}

.aav-bar-compliant {
  fill: #00f3ff;
  transition: width 0.3s ease;
}

.aav-bar-exceeded {
  fill: #ff3c3c;
  transition: width 0.3s ease;
}

.aav-limit-line {
  stroke: #ffbd2e;
  stroke-width: 2;
  stroke-dasharray: 4 2;
}

.aav-limit-text {
  font-family: var(--font-mono);
  font-size: 11px;
  font-weight: 600;
  fill: #ffbd2e;
}

.aav-gauge-label {
  font-family: var(--font-mono);
  font-size: 12px;
  font-weight: 500;
  fill: var(--ink-secondary);
}

.aav-falsification-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 1rem;
  margin-top: 1rem;
}

@media (max-width: 768px) {
  .aav-falsification-grid {
    grid-template-columns: 1fr;
  }
}

.aav-tropism-card {
  grid-column: 1 / -1;
  border-left: 3px solid var(--neon-cyan);
}

.aav-tropism-val {
  font-size: 0.92rem;
  line-height: 1.45;
  color: var(--neon-cyan);
}

.aav-falsification-card {
  background: rgba(255, 255, 255, 0.03);
  border: 1px solid rgba(255, 255, 255, 0.08);
  border-left: 3px solid var(--neon-cyan);
  border-radius: 8px;
  padding: 1rem 1.15rem;
  display: flex;
  flex-direction: column;
  gap: 0.5rem;
}

.aav-falsification-card.card-amber {
  border-left-color: var(--lime);
}

.aav-falsification-title {
  font-family: var(--font-mono);
  font-size: 0.85rem;
  font-weight: 600;
  color: var(--ink-primary);
  display: flex;
  align-items: center;
  gap: 0.4rem;
}

.aav-falsification-text {
  font-family: var(--font-body);
  font-size: 0.82rem;
  font-weight: 400;
  color: var(--ink-secondary);
  line-height: 1.5;
  margin: 0;
}

/* SVG Animations & Reconstitution Stage */
.delivery-anim-path {
  stroke-dasharray: none;
  stroke-dashoffset: 0;
}

.aav-splice-path {
  stroke-dasharray: none;
  stroke-dashoffset: 0;
}

@media (prefers-reduced-motion: no-preference) {
  .delivery-anim-path {
    stroke-dasharray: 1;
    stroke-dashoffset: 1;
    animation: delivery-line-draw 2s ease forwards;
  }

  .aav-splice-path {
    stroke-dasharray: 1;
    stroke-dashoffset: 1;
    animation: aav-line-draw 1.8s ease forwards;
  }

  .aav-pulse-dot,
  .delivery-kinetics-pulse {
    animation: delivery-pulse-dot 2.5s ease-in-out infinite;
    transform-box: fill-box;
    transform-origin: center;
  }
}

@keyframes delivery-line-draw {
  to {
    stroke-dasharray: none;
    stroke-dashoffset: 0;
  }
}

@keyframes aav-line-draw {
  to {
    stroke-dasharray: none;
    stroke-dashoffset: 0;
  }
}

@keyframes delivery-pulse-dot {
  0%, 100% {
    opacity: 0.5;
    transform: scale(0.9);
  }
  50% {
    opacity: 1;
    transform: scale(1.3);
  }
}

/* Animation Pause Button & States */
.bench-anim-toggle-btn {
  font-family: var(--font-mono);
  font-size: 0.72rem;
  font-weight: 500;
  min-height: 28px;
  padding: 0.25rem 0.65rem;
  border-radius: 4px;
  background: rgba(255, 255, 255, 0.05);
  border: 1px solid rgba(255, 255, 255, 0.15);
  color: var(--ink-secondary);
  cursor: pointer;
  transition: background 0.2s ease, border-color 0.2s ease, color 0.2s ease;
}

.bench-anim-toggle-btn:hover,
.bench-anim-toggle-btn:focus-visible {
  background: rgba(0, 243, 255, 0.1);
  border-color: var(--neon-cyan);
  color: var(--neon-cyan);
}

.bench-anim-toggle-btn[aria-pressed="true"] {
  background: rgba(255, 189, 46, 0.15);
  border-color: #ffbd2e;
  color: #ffbd2e;
}

svg [hidden],
g[hidden],
g[hidden] * {
  display: none !important;
}

.is-anim-paused .delivery-anim-path,
.is-anim-paused .aav-splice-path,
.is-svg-frozen-time .delivery-anim-path,
.is-svg-frozen-time .aav-splice-path {
  stroke-dasharray: none !important;
  stroke-dashoffset: 0 !important;
  animation: none !important;
}

.is-anim-paused .aav-pulse-dot,
.is-anim-paused .delivery-kinetics-pulse,
.is-svg-frozen-time .aav-pulse-dot,
.is-svg-frozen-time .delivery-kinetics-pulse {
  animation-play-state: paused !important;
}

/* Reduced Motion Compliance */
@media (prefers-reduced-motion: reduce) {
  .delivery-slider,
  .switch-btn,
  .candidate-chip,
  .download-btn,
  .copy-btn,
  .warning-card,
  .aav-bar-compliant,
  .aav-bar-exceeded,
  .bench-anim-toggle-btn {
    transition: none !important;
  }
  .delivery-anim-path,
  .aav-splice-path,
  .aav-pulse-dot,
  .delivery-kinetics-pulse {
    animation: none !important;
    stroke-dasharray: none !important;
    stroke-dashoffset: 0 !important;
  }
}

/* ==========================================================================
   Repeat-Dosing Neutralizing Antibody (NAb) & Epithelial Turnover Simulator
   ========================================================================== */
#vector-redosing-explorer {
  margin-top: 3.5rem;
}

.redosing-header {
  margin-bottom: 1.5rem;
}

.redosing-control-group {
  margin: 1.5rem 0;
  display: flex;
  flex-direction: column;
  gap: 0.5rem;
}

.redosing-control-label {
  font-family: var(--font-mono, monospace);
  font-size: 0.72rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--muted, #64748b);
}

.redosing-btn-group {
  display: flex;
  flex-wrap: wrap;
  gap: 0.5rem;
}

.redosing-select-btn {
  font-family: var(--font-mono, monospace);
  font-size: 0.78rem;
  font-weight: 500;
  padding: 0.5rem 0.85rem;
  min-height: 44px;
  border-radius: 6px;
  background: rgba(255, 255, 255, 0.03);
  color: var(--ink-secondary, #94a3b8);
  border: 1px solid rgba(255, 255, 255, 0.1);
  cursor: pointer;
  transition: all 0.15s ease-in-out;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  text-align: center;
}

.redosing-select-btn:hover {
  background: rgba(255, 255, 255, 0.07);
  color: var(--ink-primary, #f0f4f8);
  border-color: rgba(255, 255, 255, 0.25);
}

.redosing-select-btn:focus-visible {
  outline: 2px solid var(--neon-cyan, #00f3ff);
  outline-offset: 2px;
}

.redosing-select-btn.active {
  background: rgba(0, 243, 255, 0.12);
  color: var(--neon-cyan, #00f3ff);
  border-color: rgba(0, 243, 255, 0.6);
  font-weight: 600;
  box-shadow: 0 0 12px rgba(0, 243, 255, 0.15);
}

.redosing-sliders-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 240px), 1fr));
  gap: 1.25rem;
  margin: 1.5rem 0;
  padding: 1rem;
  background: rgba(255, 255, 255, 0.02);
  border: 1px solid rgba(255, 255, 255, 0.06);
  border-radius: 8px;
  box-sizing: border-box;
  min-width: 0;
}

.redosing-slider-box {
  display: flex;
  flex-direction: column;
  gap: 0.45rem;
  min-width: 0;
}

.redosing-slider-head {
  display: flex;
  justify-content: space-between;
  align-items: center;
}

.redosing-slider-head label {
  font-family: var(--font-mono, monospace);
  font-size: 0.76rem;
  font-weight: 600;
  color: var(--ink-primary, #f0f4f8);
}

.redosing-slider-val {
  font-family: var(--font-mono, monospace);
  font-size: 0.85rem;
  font-weight: 700;
  color: var(--neon-cyan, #00f3ff);
}

.redosing-range {
  width: 100%;
  accent-color: var(--neon-cyan, #00f3ff);
  cursor: pointer;
  min-height: 36px;
}

.redosing-slider-hint {
  font-family: var(--font-body, system-ui, sans-serif);
  font-size: 0.75rem;
  color: var(--muted, #64748b);
  line-height: 1.35;
}

.redosing-viz-wrap {
  background: rgba(5, 8, 15, 0.9);
  border: 1px solid rgba(255, 255, 255, 0.08);
  border-radius: 8px;
  padding: 1rem 1rem 1.25rem 1rem;
  margin-top: 1.5rem;
  margin-bottom: 1.5rem;
}

.redosing-viz-toolbar {
  display: flex;
  justify-content: space-between;
  align-items: center;
  margin-bottom: 0.75rem;
  padding: 0 0.25rem;
}

.redosing-viz-legend {
  font-family: var(--font-mono, monospace);
  font-size: 0.76rem;
  color: var(--muted, #64748b);
}

.redosing-anim-btn {
  font-family: var(--font-mono, monospace);
  font-size: 0.72rem;
  font-weight: 600;
  padding: 0.35rem 0.75rem;
  min-height: 36px;
  border-radius: 4px;
  background: rgba(255, 255, 255, 0.04);
  color: var(--ink-secondary, #94a3b8);
  border: 1px solid rgba(255, 255, 255, 0.12);
  cursor: pointer;
  transition: all 0.15s ease-in-out;
}

.redosing-anim-btn:hover {
  background: rgba(255, 255, 255, 0.08);
  color: var(--ink-primary, #f0f4f8);
  border-color: rgba(255, 255, 255, 0.25);
}

.redosing-anim-btn:focus-visible {
  outline: 2px solid var(--neon-cyan, #00f3ff);
  outline-offset: 2px;
}

.redosing-durability-svg {
  width: 100%;
  height: auto;
  display: block;
}

.redosing-panel-rect {
  fill: rgba(14, 20, 32, 0.75);
  stroke: rgba(255, 255, 255, 0.08);
  stroke-width: 1;
}

.redosing-axis-line {
  stroke: rgba(255, 255, 255, 0.25);
  stroke-width: 1;
}

.redosing-grid-line {
  stroke: rgba(255, 255, 255, 0.06);
  stroke-dasharray: 2 4;
  stroke-width: 1;
}

.redosing-axis-label {
  fill: var(--muted, #64748b);
  font-family: var(--font-mono, monospace);
  font-size: 9px;
}

.redosing-10-threshold-line {
  stroke: var(--lime, #4ade80);
  stroke-width: 1.5;
}

.redosing-10-threshold-text {
  fill: var(--lime, #4ade80);
  font-family: var(--font-mono, monospace);
  font-size: 10px;
  font-weight: 700;
}

.redosing-dose-line {
  stroke: rgba(0, 243, 255, 0.35);
  stroke-width: 1;
}

.redosing-dose-tag {
  fill: var(--neon-cyan, #00f3ff);
  font-family: var(--font-mono, monospace);
  font-size: 9px;
  font-weight: 600;
}

.redosing-curve-path {
  fill: none;
  stroke: var(--neon-cyan, #00f3ff);
  stroke-width: 2.5;
  stroke-linecap: round;
}

.redosing-readout-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(180px, 1fr));
  gap: 1rem;
  margin-top: 1.5rem;
}

.redosing-readout-card {
  background: rgba(255, 255, 255, 0.025);
  border: 1px solid rgba(255, 255, 255, 0.08);
  border-radius: 8px;
  padding: 1rem;
  display: flex;
  flex-direction: column;
  gap: 0.35rem;
}

.redosing-card-lbl {
  font-family: var(--font-mono, monospace);
  font-size: 0.7rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--muted, #64748b);
}

.redosing-card-val {
  font-family: var(--font-mono, monospace);
  font-size: 1.15rem;
  font-weight: 700;
  color: var(--neon-cyan, #00f3ff);
}

.redosing-card-sub {
  font-family: var(--font-body, system-ui, sans-serif);
  font-size: 0.78rem;
  color: var(--ink-secondary, #94a3b8);
  line-height: 1.35;
}

.redosing-disclaimer {
  font-family: var(--font-body, system-ui, sans-serif);
  font-size: 0.78rem;
  color: var(--muted, #64748b);
  margin-top: 1.25rem;
  padding-top: 1rem;
  border-top: 1px solid rgba(255, 255, 255, 0.06);
  font-style: italic;
  line-height: 1.45;
}

.redosing-durability-svg.is-anim-paused .svg-draw-line {
  animation-play-state: paused !important;
}

@media (prefers-reduced-motion: reduce) {
  .redosing-durability-svg .svg-draw-line {
    animation: none !important;
    transition: none !important;
  }
}





/* Biophysical Delivery Explorers (T-0282, T-0283, T-0288) Responsive Rules */
.ptc-sim-canvas-wrap {
  width: 100%;
  max-width: 100%;
  overflow: hidden;
  margin-block: 1.25rem;
  border-radius: 8px;
}

.ptc-sim-canvas-wrap svg {
  width: 100%;
  max-width: 100%;
  height: auto;
  display: block;
}

.ptc-readouts {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(130px, 1fr));
  gap: 0.75rem;
  margin-block: 1.25rem;
  width: 100%;
  max-width: 100%;
}

.ptc-readout {
  background: rgba(255, 255, 255, 0.025);
  border: 1px solid rgba(255, 255, 255, 0.08);
  border-radius: 8px;
  padding: 0.85rem;
  display: flex;
  flex-direction: column;
  gap: 0.25rem;
  min-width: 0;
  word-break: break-word;
}

.ptc-readout-val {
  font-family: var(--font-mono, monospace);
  font-size: 1.15rem;
  font-weight: 700;
  color: var(--neon-cyan, #00f3ff);
}

.ptc-readout-lbl {
  font-family: var(--font-mono, monospace);
  font-size: 0.7rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--muted, #64748b);
}

.aso-defect-summary-card,
.aso-defect-text {
  overflow-wrap: anywhere;
  word-break: break-word;
}

.ptc-readout-val.metric-positive {
  color: #10b981;
  text-shadow: 0 0 8px rgba(16, 185, 129, 0.4);
}


/* T-0441: Aerosolized LNP Mucus Penetration & Basal Stem Cell Prime Editor */
.lnp-pe-canvas-card {
  margin-block: 1.25rem;
  background: rgba(10, 18, 32, 0.7);
  border: 1px solid rgba(0, 243, 255, 0.2);
  border-radius: 8px;
  padding: 1rem;
}

.lnp-pe-canvas-heading {
  font-family: var(--font-mono, monospace);
  font-size: 0.82rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--neon-cyan, #00f3ff);
  margin-bottom: 0.75rem;
}

.lnp-pe-canvas {
  width: 100%;
  max-width: 100%;
  height: auto;
  display: block;
  border-radius: 6px;
  background: #0a1120;
}

.aso-metric-val.val-green, .aso-readout-val.val-green {
  color: #10b981;
}

.aso-metric-val.val-amber, .aso-readout-val.val-amber {
  color: #f59e0b;
}

.aso-metric-val.val-red, .aso-readout-val.val-red {
  color: #ef4444;
}

.aso-metric-val.val-cyan, .aso-readout-val.val-cyan {
  color: #22d3ee;
}