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About this check

The sorting behind these counts was checked against labels made by a council of models; for some classes too few entries could be checked. No person has read the individual rows, and no clinician has read the class definitions.

Trial endpoint atlas

Which measures are registered together

A study can register main outcomes in several classes. For each pair of classes, this page counts the studies that registered a main outcome in both. The unit is the study, not the entry.

Registry data from ClinicalTrials.gov, an online database; the U.S. National Library of Medicine maintains its website. This lab is independent of the registry; the grouping and counts are the lab's work, not the registry's.

These are counts of what trial teams registered, not trial results. What this does not say

Not paired, by the research tools' rule: Other and No measure named.

No study in this dated copy: Intestinal current measurement.

About this dated copy
Registry data processed
Dated copy
d164700bb17d
Studies
1072
Main-outcome entries
2052
Sorted by rule
1839 entries, lexicon 0.3.2-draft
Sorted by a model, checked against an exact quote from the record
70 entries
Named no measure
32 entries
Not yet in a class
111 entries
Synthetic marker
none found (this does not prove where the data came from)
Hand check of a sample
not recorded in this data file

Registry records change; the live record on ClinicalTrials.gov is current, this page is not. Open ClinicalTrials.gov (opens another site).

Studies that registered both

Counts of studies that registered a main outcome in both classes. This shows what trials registered together, not which measures agree, replace or predict each other. Each pair is shown once, below the diagonal. The diagonal gives each class's own number of studies.

Sorted by the number of studies, then by the lexicon's order. A pair registered often is not a better pair.

Pairs with at least one study: 102
PairStudies
FEV1 and Safety and tolerabilitystudies that registered both: 32
FEV1 and Other spirometrystudies that registered both: 24
Safety and tolerability and Pharmacokineticsstudies that registered both: 22
Other spirometry and Safety and tolerabilitystudies that registered both: 14
Oxygen and carbon dioxide levels and Safety and tolerabilitystudies that registered both: 13
FEV1 and Exercise capacitystudies that registered both: 8
FEV1 and CFQ-Rstudies that registered both: 7
Other spirometry and Oxygen and carbon dioxide levelsstudies that registered both: 6
Pulmonary exacerbations and Safety and tolerabilitystudies that registered both: 6
Nutrition and growth and Inflammation markersstudies that registered both: 6
Exercise capacity and Muscle strength and endurancestudies that registered both: 6
FEV1 and Oxygen and carbon dioxide levelsstudies that registered both: 5
FEV1 and Pulmonary exacerbationsstudies that registered both: 5
FEV1 and Nutrition and growthstudies that registered both: 5
Other spirometry and CFQ-Rstudies that registered both: 5
FEV1 and Airway resistance, compliance and lung volumesstudies that registered both: 4
FEV1 and Sweat chloridestudies that registered both: 4
FEV1 and Sputum amount and propertiesstudies that registered both: 4
FEV1 and Inflammation markersstudies that registered both: 4
FEV1 and Muscle strength and endurancestudies that registered both: 4
(82 more pairs)
The other pairs, in the same order
PairStudies
Other spirometry and Sputum amount and propertiesstudies that registered both: 4
Other spirometry and Exercise capacitystudies that registered both: 4
Nutrition and growth and Glucose and cystic fibrosis-related diabetesstudies that registered both: 4
Nutrition and growth and Safety and tolerabilitystudies that registered both: 4
Glucose and cystic fibrosis-related diabetes and Safety and tolerabilitystudies that registered both: 4
Inflammation markers and Safety and tolerabilitystudies that registered both: 4
FEV1 and Lung clearance indexstudies that registered both: 3
Other spirometry and Airway resistance, compliance and lung volumesstudies that registered both: 3
Other spirometry and Pulmonary exacerbationsstudies that registered both: 3
Other spirometry and Muscle strength and endurancestudies that registered both: 3
Lung clearance index and Safety and tolerabilitystudies that registered both: 3
Airway resistance, compliance and lung volumes and Imagingstudies that registered both: 3
Sweat chloride and Safety and tolerabilitystudies that registered both: 3
CFQ-R and Inflammation markersstudies that registered both: 3
FEV1 and Pharmacokineticsstudies that registered both: 2
Other spirometry and Nutrition and growthstudies that registered both: 2
Other spirometry and Inflammation markersstudies that registered both: 2
Lung clearance index and Inflammation markersstudies that registered both: 2
Pulmonary exacerbations and Inflammation markersstudies that registered both: 2
Nutrition and growth and CFQ-Rstudies that registered both: 2
Bone mineral density and Imagingstudies that registered both: 2
CFQ-R and Exercise capacitystudies that registered both: 2
Inflammation markers and Gene expression and methylationstudies that registered both: 2
FEV1 and Glucose and cystic fibrosis-related diabetesstudies that registered both: 1
FEV1 and Imagingstudies that registered both: 1
Other spirometry and Lung clearance indexstudies that registered both: 1
Other spirometry and Sinus and upper airwaystudies that registered both: 1
Other spirometry and Imagingstudies that registered both: 1
Other spirometry and Pharmacokineticsstudies that registered both: 1
Lung clearance index and Airway resistance, compliance and lung volumesstudies that registered both: 1
Lung clearance index and Pulmonary exacerbationsstudies that registered both: 1
Lung clearance index and Nutrition and growthstudies that registered both: 1
Lung clearance index and CFQ-Rstudies that registered both: 1
Lung clearance index and Imagingstudies that registered both: 1
Lung clearance index and Sputum amount and propertiesstudies that registered both: 1
Airway resistance, compliance and lung volumes and Oxygen and carbon dioxide levelsstudies that registered both: 1
Airway resistance, compliance and lung volumes and Pulmonary exacerbationsstudies that registered both: 1
Airway resistance, compliance and lung volumes and CFQ-Rstudies that registered both: 1
Airway resistance, compliance and lung volumes and Sputum amount and propertiesstudies that registered both: 1
Oxygen and carbon dioxide levels and Nutrition and growthstudies that registered both: 1
Oxygen and carbon dioxide levels and Bone mineral densitystudies that registered both: 1
Oxygen and carbon dioxide levels and Glucose and cystic fibrosis-related diabetesstudies that registered both: 1
Oxygen and carbon dioxide levels and Imagingstudies that registered both: 1
Oxygen and carbon dioxide levels and Inflammation markersstudies that registered both: 1
Oxygen and carbon dioxide levels and Gene expression and methylationstudies that registered both: 1
Oxygen and carbon dioxide levels and Exercise capacitystudies that registered both: 1
Sweat chloride and Other CFTR biomarkerstudies that registered both: 1
Sweat chloride and Pharmacokineticsstudies that registered both: 1
Pulmonary exacerbations and Nutrition and growthstudies that registered both: 1
Pulmonary exacerbations and CFQ-Rstudies that registered both: 1
Pulmonary exacerbations and Sputum amount and propertiesstudies that registered both: 1
Nutrition and growth and Bone mineral densitystudies that registered both: 1
Nutrition and growth and Sinus and upper airwaystudies that registered both: 1
Nutrition and growth and Gene expression and methylationstudies that registered both: 1
Nutrition and growth and Oxidative stress markersstudies that registered both: 1
Nutrition and growth and Pharmacokineticsstudies that registered both: 1
Nutrition and growth and Exercise capacitystudies that registered both: 1
Nutrition and growth and Muscle strength and endurancestudies that registered both: 1
Bone mineral density and Glucose and cystic fibrosis-related diabetesstudies that registered both: 1
Bone mineral density and Inflammation markersstudies that registered both: 1
Bone mineral density and Gene expression and methylationstudies that registered both: 1
Bone mineral density and Safety and tolerabilitystudies that registered both: 1
Glucose and cystic fibrosis-related diabetes and Imagingstudies that registered both: 1
Glucose and cystic fibrosis-related diabetes and Inflammation markersstudies that registered both: 1
Glucose and cystic fibrosis-related diabetes and Gene expression and methylationstudies that registered both: 1
Glucose and cystic fibrosis-related diabetes and Oxidative stress markersstudies that registered both: 1
Glucose and cystic fibrosis-related diabetes and Pharmacokineticsstudies that registered both: 1
Sinus and upper airway and CFQ-Rstudies that registered both: 1
Sinus and upper airway and Imagingstudies that registered both: 1
CFQ-R and Sputum amount and propertiesstudies that registered both: 1
CFQ-R and Safety and tolerabilitystudies that registered both: 1
CFQ-R and Muscle strength and endurancestudies that registered both: 1
Imaging and Sputum amount and propertiesstudies that registered both: 1
Imaging and Inflammation markersstudies that registered both: 1
Imaging and Exercise capacitystudies that registered both: 1
Sputum amount and properties and Inflammation markersstudies that registered both: 1
Sputum amount and properties and Exercise capacitystudies that registered both: 1
Sputum amount and properties and Muscle strength and endurancestudies that registered both: 1
Inflammation markers and Oxidative stress markersstudies that registered both: 1
Inflammation markers and Muscle strength and endurancestudies that registered both: 1
Gene expression and methylation and Safety and tolerabilitystudies that registered both: 1
Safety and tolerability and Exercise capacitystudies that registered both: 1
Every pair at once (table of all pairs)

Every pair at once: studies per pair of classes, 24 classes.

Scroll sideways to see all 24 columns.

ClassFEV1Other spirometryLung clearance indexAirway resistance, compliance and lung volumesOxygen and carbon dioxide levelsSweat chlorideNasal potential differenceOther CFTR biomarkerPulmonary exacerbationsNutrition and growthBone mineral densityGlucose and cystic fibrosis-related diabetesSinus and upper airwayCFQ-RImagingMucociliary clearanceSputum amount and propertiesInflammation markersGene expression and methylationOxidative stress markersSafety and tolerabilityPharmacokineticsExercise capacityMuscle strength and endurance
FEV1studies naming FEV1: 164
Other spirometry24studies naming Other spirometry: 46
Lung clearance index31studies naming Lung clearance index: 26
Airway resistance, compliance and lung volumes431studies naming Airway resistance, compliance and lung volumes: 13
Oxygen and carbon dioxide levels5601studies naming Oxygen and carbon dioxide levels: 22
Sweat chloride40000studies naming Sweat chloride: 16
Nasal potential difference000000studies naming Nasal potential difference: 16
Other CFTR biomarker0000010studies naming Other CFTR biomarker: 16
Pulmonary exacerbations53110000studies naming Pulmonary exacerbations: 40
Nutrition and growth521010001studies naming Nutrition and growth: 46
Bone mineral density0000100001studies naming Bone mineral density: 8
Glucose and cystic fibrosis-related diabetes10001000041studies naming Glucose and cystic fibrosis-related diabetes: 49
Sinus and upper airway010000000100studies naming Sinus and upper airway: 9
CFQ-R7511000012001studies naming CFQ-R: 23
Imaging11131000002110studies naming Imaging: 41
Mucociliary clearance000000000000000studies naming Mucociliary clearance: 16
Sputum amount and properties4411000010000110studies naming Sputum amount and properties: 21
Inflammation markers42201000261103101studies naming Inflammation markers: 42
Gene expression and methylation000010000111000002studies naming Gene expression and methylation: 7
Oxidative stress markers0000000001010000010studies naming Oxidative stress markers: 12
Safety and tolerability32143013300641401000410studies naming Safety and tolerability: 220
Pharmacokinetics2100010001010000000022studies naming Pharmacokinetics: 91
Exercise capacity8400100001000210100010studies naming Exercise capacity: 49
Muscle strength and endurance43000000010001001100006studies naming Muscle strength and endurance: 11

The pairs as CSV

Where the data come from, and what the lab changed

Registry data from ClinicalTrials.gov, an online database; the U.S. National Library of Medicine maintains its website. This lab is independent of the registry; the grouping and counts are the lab's work, not the registry's.

Source
ClinicalTrials.gov
Data processed by the registry
(as given: 2026-10-09T09:00:05; the registry gives no time zone)
Live record
Registry records change; the live record on ClinicalTrials.gov is current, this page is not.
License
The lab's licence covers its own tags, code and counts only; registry text and fields remain ClinicalTrials.gov data under its terms.
No warranty
ClinicalTrials.gov states that the U.S. Government makes no warranties, expressed or implied, about its data and assumes no liability for any party's use of them.
Sponsor responsibility
Study sponsors and investigators write and are responsible for their own records. The registry's Disclaimer says the U.S. government "does not review or approve the safety and science of all studies listed on this website" and that NLM staff only review study information for apparent errors, deficiencies or inconsistencies. See the registry's Disclaimer.
Disclaimer page
https://clinicaltrials.gov/about-site/disclaimer
Disclaimer last updated
2023-08-03
The registry's terms page, the dated copy's date, every change the lab made, and keeping the data
Dated copy taken
(2026-10-11 03:59:17 UTC)
Registry terms
Terms and Conditions of ClinicalTrials.gov (opens another site) (last updated )
Changes the lab made
  1. Primary-outcome wording was classified into classes by the versioned rule lexicon 0.3.2-draft (sha256 f4bd1af4c664); a model-proposed class is counted only when its quote is an exact piece of the registry text.
  2. Studies were left out by stated scope rules, with these counts: X1 554, X2 7, X3 0, X4 91, X5 48, X6 0 (explained in trial-atlas-data-dictionary.txt; X6 is a person's exclusion list).
  3. Start dates without a recorded date type are counted as their own kind; no type is assumed.
  4. No registry wording was clipped by these tools; any clipping on a published page must be added to this list.
  5. Registry pages were re-saved as UTF-8 JSON after parsing; values and key order are kept, whitespace is not.
  6. This page and its downloads show counts only: no registry wording, trial ids or sponsor names.
  7. Start years are also grouped into five-year periods for narrow screens; the yearly counts are in the downloads.
  8. Phase codes are written in plain words (PHASE1 as Phase 1, PHASE1/PHASE2 as Phase 1/2, EARLY_PHASE1 as Early phase 1); NA is shown as written, and a study with no phase is shown as None given.
Keeping the data
The registry's terms apply for as long as the data are kept, in any copy, file or page made from them.
Third party copyright
Some registry data may be subject to third-party copyright, and the data carry an international copyright outside the United States and its Territories or Possessions.
Keep current
The registry says it is updated daily and that data in any publication or distribution should be kept current at all times. This copy is dated and may be out of date; the live record is the current one.

Not affiliated with the Cystic Fibrosis Foundation or with ClinicalTrials.gov. This is an independent lab. Its work is research, not medical advice.

Registry data from ClinicalTrials.gov, an online database; the U.S. National Library of Medicine maintains its website. This lab is independent of the registry; the grouping and counts are the lab's work, not the registry's.